Acknowledgments

The authors are especially grateful to:

• Keith S. Wilson (York, UK) one of the originators of the software;

• Zbyszek Dauter (Brookhaven, USA) and Richard Morris (EMBL Hamburg, Germany) for significant contributions to the software development;

• Eleanor Dodson (York, UK), Jozef Sevcik (Bratislava, SLO), Phil Evans (Cambridge, UK), Susanna Butterworth (York, UK), Titia Sixma (NKI Amsterdam, The Netherlands) and Erik van Asselt (Univ. Groningen, The Netherlands) for valuable suggestions.