In consideration of acceptance of the terms stated herin by
        and between The University of Oregon (hereinafter referred to as
        the "LICENSOR") and your institution (hereinafter referred to as
        the "LICENSEE"), one copy of TNT (Copyright 1992 by the University
        of Oregon, Institute of Molecular Biology), a system of computer
        programs for least-square macromolecular refinement against
        standard stereochemical and x-ray diffraction data, will be
        delivered to you. The computer programs, and files are hereinafter
        referred to collectively as the SOFTWARE.

                                      TERMS

        1. A non-exclusive, nontransferable license is granted to the
        LICENSEE to install and use the SOFTWARE on an appropriate
        computer system located at LICENSEE'S institution to which the
        LICENSEE has authorized access. Use of the SOFTWARE is restricted
        to the LICENSEE and collaborators at his/her institution who have
        agreed to accept the terms of this license.
        
        2. The LICENSOR retains ownership of all materials (including
        SOFTWARE and documentation) delivered to the LICENSEE.
        
        3. The LICENSEE shall not use the SOFTWARE for any purpose
        (research or otherwise) that is supported by a "for profit"
        organization without prior written authorization from the
        LICENSOR.

        4. The LICENSEE shall not disclose the delivered SOFTWARE in any
        form to third parties without prior written authorization from
        the LICENSOR.

        5. The LICENSEE may make a reasonable number of copies of the
        SOFTWARE for the purpose of backup, maintenance of the SOFTWARE
        or the development of derivative works based on the SOFTWARE.
        These additional copies will carry the copyright notice of the
        LICENSOR and will be controlled by this license, and will be
        destroyed by the LICENSEE upon termination of the license.

        6. If the LICENSEE receives a request to furnish all or any
        portion on the SOFTWARE to any third party, he or she will not
        fulfill such a request and will refer it in writing to the
        LICENSOR.

        7. THE LICENSOR AGREES THAT THE SOFTWARE IS FURNISHED ON AN "AS
        IS" BASIS AND THAT THE LICENSOR IN NO WAY WARRANTS THE SOFTWARE
        OR ANY OF ITS RESULTS AND IS IN NO WAY LIABLE FOR ANY USE
        LICENSEE MAKES OF THE SOFTWARE.

        8. The term of this license shall not be limited in time.
        
        9. LICENSEE shall reference the SOFTWARE in all printed or
        electronic publications (including poster presentations) in which
        the SOFTWARE was utilized and made a material contribution to the
        processing, refinement or understanding of the data or concept
        presented therein.  The recommended reference is "Tronrud, D.E.,
        Ten Eyck, L.F., & Matthews, B.W. (1987). An Efficient General-
        Purpose Least-Squares Refinement Program for Macromolecular 
        Structures. Acta Cryst A, 43, 489-501"

             To evidence your acceptance of the terms and conditions set
        forth above, please sign in the indicated space below and return
        this letter to:

             Director
             Technology Transfer
             1238 University of Oregon
             Eugene, Oregon 97403-1238

             Voice: (541) 346-3176


        READ AND APPROVED:

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        E-mail Address: