Teaching module
Introduction.
Division of scripts in classes
GENERAL
Introduction.
Visualisation
Display modes using Hypothase (AA0001)
Colouring schemes for Hypothase residues (AA0002)
Colouring schemes identifies aspects of proteins (AA0003)
Ramachandran plot of Hypothase (AA0004)
Contacts in Crambin (AA0005)
Contact plot of Crambin (AA0006)
Surface plots of HLA (AA0007)
Structural superposition of Hemoglobin A and B (AA0008)
Colouring schemes for the display of Hypothase residues (AA0009)
Surface plot of Hypothase (AA0010)
Primary Structure
Primary structure of Hypothase (AA0101)
Classes of amino acids (AA0102)
Secondary Structure
Secondary structure example - alpha helix (AA0201)
Secondary structure example - beta sheet (AA0202)
Secondary structure example - beta sheet (AA0205)
Secondary structure example - alpha helix (AA0203)
Secondary structure example - beta sheet (AA0204)
Secondary structure example - beta sheet (AA0206)
Ramachandran plot of Hypothase (AA0207)
Tertiary Structure
Combination of secondary structures (AA0301)
The structure of HIV-1 Protease sub-unit A (AA0302)
The structure of Hypothase (AA0303)
Example of anti-parallel beta strands (AA0304)
Example of parallel beta strands in Flavodoxin (AA0305)
Example of (anti)parallel beta barrel in Plastocyanin (AA0306)
Example of the helix-loop-helix motif in Calmodulin (AA0307)
Example of the hairpin-beta motif in Erabutoxin (AA0308)
Example of the beta-alpha-beta-alpha motif in TIM (AA0309)
Example of the helix-bundle motif in Myohemerythrin (AA0310)
Quaternary Structure
The complete structure of Triose Phosphate Isomerase (AA0401)
The complete structure of HIV-1 Protease (AA0402)
Problem 1: HIV-1 protease inhibitors
Introduction.
Structure of HIV-1 Protease
Introduction (BB0000)
Primary structure sub-unit A (BB0101)
Tertiary structure sub-unit A (BB0102)
Tertiary structure sub-unit A (BB0103)
Quaternary structure sub-units A & B (BB0104)
Quaternary structure sub-units A & B (BB0105)
Superposed sub-units of HIV-1 Protease (BB0106)
Contacts between HIV-1 Protease sub-units (BB0107)
Contacts between the HIV-1 Protease sub-units (BB0108)
Homology of HIV-1 Protease with other structures
Introduction (BB0200)
Homology of HIV-1 Protease with Rouse Sarcoma virus (BB0201)
Homology of HIV-1 Protease with Penicillopepsin (BB0202)
Shows homology of HIV-1 Protease with Endothiapepsin (BB0203)
Homology of HIV-1 Protease with Rhizopuspepsin (BB0204)
Homology of Endothiapepsin with Penicillopepsin (BB0205)
Homology of Rhizopuspepsin with Endothiapepsin (BB0206)
Homology of HIV-1 Protease with Pepsin (BB0207)
Inhibition of HIV-1 Protease
Active site of HIV-1 Protease (BB0301)
Example of a HIV-1 Protease inhibitor A-74704 (BB0302)
Contacts of inhibitor A-74704 with HIV-1 Protease (BB0303)